Our new team is focusing on the pathophysiological mechanisms, methods of detection and therapeutic approaches of proteinopathies (Prions, Alzheimer's, Parkinson...). At the molecular and cellular level, we will study the conversion of soluble proteins to pathological aggregates and the environmental factors influencing this process. The detection of these different protein forms, notably by proteomics approaches, will be performed in biological samples from patients. Cellular and in vivo (mouse) stem cell related approaches, both as experimental models (IPSC) and as a main topic of investigation (neurogenesis, cell therapy, environmental pollutants) will be also at the center of our research as follows. Three main research aims with referent PI but actually involving the whole team in a complementary fashion are described below.